SOLUBILIZATION OF PROTEIN AGGREGATES

摘要

A source of proteins in insoluble form and a source of at least one cationic surfactant are provided. The insoluble protein is then treated with the cationic surfactant(s) in an amount sufficient to effect solubilisation without substantial modification to the structural backbone of the protein. The treatment is particularly applicable to the solubilisation and recovery of biologically active proteins synthesised by microorganisms and eukaryotic cell lines which have been modified by recombinant DNA technology.