Radiopharmaceuticals for localization of thromboembolic disease

摘要

The invention relates to radiopharmaceuticals useful for specifically localizing blood clots during the diagnosis and treatment of thromboembolic disorders. In one embodiment, the invention comprises a method for preparing and using radioactive urokinase. A novel process for producing urokinase labeled with technetium-99m involves combination of urokinase with the nuclide in a basic solution containing ferric chloride and ascorbic acid, and then adjusting the pH to give an acidic condition in the solution. Radioactively-labeled streptokinase and fibrinokinase are also used to localize thromboembolic disorders.