Anthracycline derivatives, a process for their preparation and pharmaceutical compositions containing them.

摘要

Anthracycline derivatives of adriamycin and daumonycin of formula: <CHEM> wherein R<1> is a hydrogen atom, a hydroxyl group, an alkanoyloxy group having a carbon number of 2 to 7 or a phenylacetyl group, and R<2> ia an alkyloxyethyl, a tetrahydrofuranyl, a tetrahydropyranyl, a 6-methoxytetrahydropyranyl, a 6-carbomethoxytetrahydropyranyl or a 6-acetoxymethyltetrahydropyranyl group, excluding the case where R<1> is a hydrogen atom or a hydroxyl group and simultaneously R<2> is a tetrahydropyranyl group, are prepared by the reaction of I (R2 = H) with R2OH or a derivative; they are useful as antitumor agents.