| 发明名称 | Nucleic acids encoding anti-IL-17F antibodies and methods of use thereof | ||
| 摘要 | This invention provides fully human monoclonal antibodies that recognize IL-17F and/or the heterodimeric IL-17A/IL-17F complex, but do not recognize IL-17A. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic. | ||
| 申请公布号 | US9475873(B2) | 申请公布日期 | 2016.10.25 |
| 申请号 | US201414507108 | 申请日期 | 2014.10.06 |
| 申请人 | NOVIMMUNE SA | 发明人 | Masternak Krzysztof;Rousseau Francois |
| 分类号 | C12N15/13;C07K16/24;A61K39/395;A61K39/00 | 主分类号 | C12N15/13 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. An isolated nucleic acid encoding an anti-IL-17F antibody heavy chain variable region and/or light chain variable region, or an antigen-binding fragment thereof, wherein said antibody comprises: (a) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO: 45; (b) a VH CDR2 region comprising the amino acid sequence of SEQ ID NO: 46; (c) a VH CDR3 region comprising the amino acid sequence of SEQ ID NO: 47; (d) a VL CDR1 region comprising the amino acid sequence of SEQ ID NO: 74; (e) a VL CDR2 region comprising the amino acid sequence of SEQ ID NO: 75; and (f) a VL CDR3 region comprising the amino acid sequence of SEQ ID NO: 76. | ||
| 地址 | Geneva CH | ||