发明名称 |
WATER SOLUBLE DISPERSIONS OF CHLORTHALIDONE AND PROCESS FOR PREPARING THEM |
摘要 |
Water-soluble dispersions of chlorthalidone are prepared by a process comprising: (a) forming a solution comprising a water soluble pharmaceutically acceptable polymeric carrier and a C1-C4 alkanol, (b) dissolving chlorthalidone in the solution thus formed, and (c) removing the C1-C4 alkanol from the solution by evaporation, the amount of said carrier being effective to suppress substantially the formation of the alkyl ether by-product from the reaction of chlorthalidone with the C1-C4 alkanol. A preferred water soluble carrier is polyvinylpyrrolidon and a preferred C1-C4 alkanol is methanol. |
申请公布号 |
DE3467707(D1) |
申请公布日期 |
1988.01.07 |
申请号 |
DE19843467707 |
申请日期 |
1984.03.15 |
申请人 |
BOEHRINGER INGELHEIM LTD. |
发明人 |
PANDIT, NEVEDITA, DR.;HORHOTA, STEPHEN T., DR. |
分类号 |
C07D209/48;A61K9/14;A61K9/16;A61K31/40;A61K31/403;A61K31/4035;A61P7/10;(IPC1-7):A61K47/00;A61K31/00 |
主分类号 |
C07D209/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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