发明名称 Oral compositions containing polyguanidinium compounds and methods of manufacture and use thereof
摘要 The invention describes the modification of polyamine-based materials to form polyguanidine compounds that are useful for their antimicrobial, anticaries, and muccoadhesive properties. The present invention also relates to methods for preventing or treating periodontal disease and caries which include delivering a therapeutically effective amount of an oral composition containing a polyguanidine compound into an oral cavity.
申请公布号 US8758729(B2) 申请公布日期 2014.06.24
申请号 US200913266930 申请日期 2009.05.18
申请人 Colgate-Palmolive Company 发明人 Nowak Andrew;Pilch Shira;Masters Jim
分类号 A61Q11/00;A61K6/00;A61K8/00;A61K8/02;A61K8/24;A61K8/25;A61K8/43 主分类号 A61Q11/00
代理机构 代理人 Lee Howard C.
主权项 1. An oral composition, comprising: a. a polyguanidine compound of Formula (I): wherein: X denotes an orally acceptable counterion; Z is CH or N; R1, R2, and R3 are each independently a hydrogen or a linear or branched, saturated or unsaturated, optionally hydroxylated C1 to C16 alkyl radical; A denotes a linear or branched, saturated or unsaturated, optionally hydroxylated C1 to C16 alkyl radical; or A denotes a linear or branched, saturated or unsaturated, C1 to C16 alkylene radical optionally substituted with at least one radical selected from the group consisting of: a hydroxyl, carboxyl, or carboxylate radical or a halogen; the alkylene radical optionally containing at least one function group selected from the group consisting of: an amine, ether, thioether, ester, amide, carbamate, urea, C6 aryl or C3 to C8 cyclanyl ring optionally substituted with a C1-C8 alkyl, hydroxyl or halogen; or A denotes one or more C6 or C7 aryl or C5 to C7 cyclanyl rings unsubstituted or substituted with a C1-C8 alkyl, a hydroxyl group or a halogen; or A denotes a C10 to C14 polyaryl or C6 to C10 polycyclanyl chain, which may be interrupted with at least one function group selected from the group consisting of: a C1 to C8 alkylene radical, amine, amide, ether, thioether, hydrogen atom, carbamate or urea; and n denotes an integer between 2 and 5,000; b. an orally acceptable carrier; c. a bioacceptable glass composition comprising 40-60% SiO2, 10-30% CaO2, 10-35% Na2O, 2-8% P2O5, 0-25% CaF2, and 0-10% B2O3; and d. a small particle silica having an average particle size of 0.01 μm-10 μm.
地址 New York NY US