发明名称 1, 3-DIHYDROIMIDAZOLE- 2 -THIONE DERIVATIVES AS INHIBITORS OF DOPAMINE-BETA-HYDROXYLASE
摘要 <p>Compounds of formula I and a method for their preparation are described: where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies -alkyl-aryl or -alkyl-heteroaryl; X signifies CH2, oxygen atom or sulphur atom; n is 2 or 3; including the individual (R)- and (S)-enantiomers or mixtures of enantiomers thereof; and including pharmaceutically acceptable salts and esters thereof. The compounds have potentially valuable pharmaceutical properties for the treatment of cardiovascular disorders such as hypertension and chronic heart failure.</p>
申请公布号 SI2155731(T1) 申请公布日期 2011.05.31
申请号 SI20080030191T 申请日期 2008.05.06
申请人 BIAL - PORTELA & CA, S.A. 发明人 SOARES DA SILVA PATRICIO MANUEL VIEIRA ARAUJO;LEARMONTH DAVID ALEXANDER;BELIAEV ALEXANDER
分类号 A61K31/4164 主分类号 A61K31/4164
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