发明名称 |
Polypeptides, derivatives and uses thereof |
摘要 |
The invention provides a compound having formula X1-Arg-Xaa-Arg-X2 in which X1 and X2 are up to 30 amino acid residues and Xaa is an amino acid residue. A preferred compound is the tripeptide Arg-Glu-Arg which corresponds to amino acid residues 328 to 330 of human amyloid precursor protein. The invention further provides a derivative of a polypeptide having the formula: X1-Arg-Xaa-Arg-X2 wherein X1 and X2, which may be the same or different, each represents from zero to 30 natural or synthetic amino acid residues or derivatives thereof and Xaa represents a natural or synthetic amino acid residue or derivative thereof, at least one functional group of at least one said amino acid residue or derivative thereof being protected by a protective group. The compounds of the invention are believed to be useful in the treatment of Alzheimer's disease and as cognitive enhancers.
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申请公布号 |
US7622446(B2) |
申请公布日期 |
2009.11.24 |
申请号 |
US20030475281 |
申请日期 |
2003.10.16 |
申请人 |
THE OPEN UNIVERSITY |
发明人 |
MILEUSNIC RADMILA;ROSE STEVEN PETER RUSSELL |
分类号 |
A61K38/06;A61K38/00;A61K38/07;A61K38/08;A61K47/48;C07K1/00;C07K1/107;C07K2/00;C07K5/08;C07K5/083;C07K5/09;C07K5/11;C07K7/04;C07K7/06;C07K14/47 |
主分类号 |
A61K38/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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