发明名称 |
Process for preparing R-(-)-carnitine from S-(-)-chlorosuccinic acid or derivatives thereof |
摘要 |
<p>A process for the preparation of S-(-)-chlorosuccinic acid comprising the reaction between S-(+)-aspartic acid and sodium nitrite in a hydrochloric acid-aqueous milieu being said S-(+)-aspartic acid suspended in demineralised water in a w/v ratio ranging from 1 kg/L to 0.5 kg/L, and concentrated hydrochloric acid being added in a ratio of S-(+)-aspartic acid to hydrochloric acid ranging from 0.35 kg/L to 0.55 kg/L, in the presence of sodium chloride, said S-(+)-aspartic acid and said sodium chloride being in a molar ratio ranging from 1:0.3 to 1:0.5, the improvement wherein consists in the isolation by precipitation of the reaction product by cooling the reaction mixture at a temperature ranging from -10 DEG C to -20 DEG C.</p> |
申请公布号 |
CZ20013816(A3) |
申请公布日期 |
2002.02.13 |
申请号 |
CZ20010003816 |
申请日期 |
2000.05.12 |
申请人 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S. P. A. |
发明人 |
MELLONI PIERO;CERRI ALBERTO;SANTAGOSTINO MARCO |
分类号 |
C07D307/60;C07B53/00;C07C51/363;C07C51/377;C07C51/48;C07C51/56;C07C55/32;C07C55/40;C07C69/63;C07C227/08;C07C227/30;C07C227/32;C07C229/22;C07C309/66;(IPC1-7):C07C227/32 |
主分类号 |
C07D307/60 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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