发明名称 |
Bile acid containing prodrugs with enhanced bioavailability |
摘要 |
Many compounds have poor bioavailability or variable bioavailability because of poor absorption of the compound in the small intestine. Conjugation of the compound with bile acid to form a prodrug will increase the bioavailibility of the compound and/or reduce the bioavailability variability of the compound because of the active transport of the prodrug by the intestinal bile acid transporter and because of increased lipophilic nature of the prodrug. A linker group can be used between the bile acid and the compound. One example of a bile acid containing prodrug is acyclovir valylchenodeoxycholate, where valine is the linker group. Another example of this prodrug is atenolol cholic acid amide. |
申请公布号 |
AU5322601(A) |
申请公布日期 |
2001.10.23 |
申请号 |
AU20010053226 |
申请日期 |
2001.04.06 |
申请人 |
UNIVERSITY OF MARYLAND, BALTIMORE;ANDREW COOP;DEAN Y. MAEDA;KIMBERLEY A. LENTZ;JAMES E. POLLI |
发明人 |
JAMES E. POLLI;ANDREW COOP;DEAN Y. MAEDA;KIMBERLEY A. LENTZ |
分类号 |
A61K47/48;A61K;A61K31/165;A61K31/522;A61K31/575;A61K31/58;A61K35/50;A61K39/395;A61K39/40;A61K39/42;A61K39/44;A61P9/04;A61P31/12;A61P43/00;C07J9/00;C07J41/00;C07J43/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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