| 发明名称 |
Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277 |
| 摘要 |
Biologically active mutant tissue plasminogen activators are disclosed wherein site directed mutagenesis, for example, of a two-chain activation site renders said mutants resistant to conversion to the two-chain form.
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| 申请公布号 |
US5073494(A) |
申请公布日期 |
1991.12.17 |
| 申请号 |
US19900522480 |
申请日期 |
1990.05.11 |
| 申请人 |
GENENTECH, INC. |
发明人 |
HEYNEKER, HERBERT L.;VEHAR, GORDON A. |
| 分类号 |
A61K38/00;C12N9/72;C12N15/10;C12N15/67;C12N15/71 |
主分类号 |
A61K38/00 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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