| 摘要 |
Title compds. (I; R, R1 = H, lower alkyl, lower alkoxy, halogen or hydroxy group; m, m; = 1,2; n, n' = 1,2,3; p = 1-4),useful for treatment of melancholia, were prepd. by reaction of 1,3-dihydro-3-phenylspiro(isobenzofuran-cycloazalkane)(II; R;, R1 = H, lower alkyl, lower alkoxy, halogen) with compd.(III; X = Cl, Br; q = 0, 1, 2, 3) in the presence of org. solvent and acid eliminating agent. Thus, K2CO3 3.0g and chloromethyldimethylphosphineoxide 1.39g were added in the 1,3-dihydro-3-phenylspiro(isobenzofuran-1,4;-piperidine) 2.65g in dimethylformamide 40ml soln. and heated at 100≦̸C for 20hr to give compd.(I).
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