METHODS OF MAKING COMPOUNDS

摘要

A biological method of making a compound having formula (I), wherein R<1> is CH=CH2, COOH, CH2-CH3 or OH; R<3> is OH, or -OCH3; R<4> is OH; and R<2>, R<5> and R<6> are hydrogen, comprises treating a substrate comprising at least 0.5 % on a dry weight basis of a compound of formula (II), wherein R<1> is CH=CH-COOH; and R<2>, R<3>, R<4>, R<5> and R<6> are as defined above, with one or more fungus (including yeast) microorganisms in viable or non-viable forms and/or an enzymic and/or cell free extract and/or engineered enzyme or cell derived from said microorganisms.