USES OF FIBROBLASTS OR SUPERNATANTS FROM FIBROBLASTS FOR THESUPPRESSION OF IMMUNE RESPONSES IN TRANSPLANTATION

摘要

Disclosed is a method of inducing a reduced immune response to a transplant in a recipient by treating said recipient with an amount of fibroblasts or a supernatant from a fibroblast culture effective to reduce or inhibit host rejection of the transplant. The fibroblasts or a supernatant from a fibroblast culture can be administered before, at the same time as, or after the transplant. This method is effective in reducing an immune response to a transplant without compromising the immune response to other foreign antigen s. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease.