1-STYRYLISOQUINOLINE DERIVATIVES, DRUGS BASED THEREON, AND PROCESS FOR PREPARATION AND USE THEREOF

摘要

FIELD: medicine. SUBSTANCE: claimed invention describes drugs having anxyolytic activity and containing as active ingredient 1-styrylisoquinoline derivatives of general formula (I):wherein n is 1,2,3 or 4; R may have the same or different meanings and is hydrogen, lower alkyl, lower alkoxy or hydroxy or two R substituents connected with adjacent carbon atoms may form in combination with each other, alkylenedioxy group; Ris hydrogen or lower alkyl and Ar is optionally substituted aryl or heteroaryl. There are known in the art some compounds of general formula (I). However most of these compounds have not been described in literature. The claimed invention describes process for preparing novel compounds of general formula (I) which comprises reacting compounds of formula II:, with aldehyde of general formula (III): Ar-CHO in the presence of condensing agent or acid catalyst. EFFECT: improved properties of the drugs.