Compositions and Methods Related To Calcitriol

摘要

Contemplated compositions and methods are drawn to use of various boron-containing compounds to temporarily and transiently increase endogenous blood calcitriol concentration. The boron-containing compound is preferably a carbohydrate-boron complex having sufficient stability to achieve measurable quantities of the complex in blood upon oral administration of the complex.

主权项

1. A method of treating a condition associated with an abnormal calcitriol level in serum of a mammal, comprising:
administering a carbohydrate-boron complex to the mammal at a dosage and schedule that transiently increases endogenous blood calcitriol and that simultaneously maintains endogenous blood calcidiol concentration in the mammal; wherein the condition is an inflammatory condition or overreaction of the immune system; and wherein the dosage and schedule are effective to transiently increase the endogenous blood calcitriol in an amount of at least 20% over baseline.