摘要 |
<p>Supports having azlactone-functional surfaces, adduct supports prepared from such azlactone-functional supports, and methods of preparing both are disclosed. Azlactone functionality is introduced to surfaces of a pre-existing support in a manner which retains useful physical and chemical characteristics of the pre-existing support. One method involves exposing surfaces with high energy radiation to generate free radical reaction sites on the surfaces and causing azlactone-functional moieties to react with the free radical reaction sites. Another method involves coating surfaces with azlactone monomers, crosslinking monomers, and optionally co-monomers and polymerizing the monomers to form a polymerized coating of azlactone-functionality on the surfaces. Another method involves dispersion polymerization of azlactone-functional moieties to produce azlactone-functional particles within pores and interstices of a pre-existing support. Adduct supports are formed by coupling nucleophilic reagents, such as biologically active materials, to azlactone-functional moieties of the support.</p> |
申请人 |
MINNESOTA MINING AND MFG. CO., SAINT PAUL, MINN., US |
发明人 |
GAGNON, DAVID, R., SAINT PAUL, MN 55133-3427, US;COLEMAN, PATRICK, L., SAINT PAUL, MN 55133-3427, US;DRTINA, GARY, J., SAINT PAUL, MN 55133-3427, US;KWON, OH-SEUNG, SAINT PAUL, MN 55133-3427, US;LYONS, CHRISTOPHER, S., SAINT PAUL, MN 55133-3427, US;MILBRATH, DEAN, S., SAINT PAUL, MN 55133-3427, US;RASMUSSEN, JERALD, K., SAINT PAUL, MN 55133-3427, US;STAHL, JULIE, B., SAINT PAUL, MN 55133-3427, US |