| 摘要 |
This invention relates to a process for the preparation of alpha -6-deoxytetracyclines, by the simultaneous reductive dehalogenation and reduction by hydrogen, in a polar solvent of the corresponding 11a-halo-6-demethyl-6-deoxy-6-methylene-tetracycline, in presence of a suitable member of the group of the tertiary phosphines, arsines and stibines, as regards the dehalogenation and of a catalyst, selected from amongst the complexes of noble metals with electron-donor ligands, soluble in the reaction medium, whereby the reaction is carried out according to the mechanism of the homogeneous catalysis. |
